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用3月龄去卵巢SD大鼠为模型，4．5mg／L已烯雌酚（diethylstilbestoli，DES）和1kg／L黄芪水提液5mL／kg·dig，每周6次，持续12周，胫骨近端不脱钙骨片测量。结果：去卵巢组大鼠的骨形成和骨吸收均增加，但骨吸收大于骨形成，骨质丢失（％Tb．Ar—68％）；黄芪水提液和DES能有效防止去卵巢大鼠的骨丢失，效应相近（与去卵巢组比较％Tb．Ar分别＋122％和＋85％，两个治疗组间P＞0．05），但作用机理不同。黄芪水提液仅抑制去卵巢后的骨吸收，而DES则同时抑制骨吸收和骨形成，但以抑制骨吸收为主。
Three-month-old ovariectomized Sprague-Dawley rats were used as a model, 4.5 mg/L diethylstilbestoli (DES) and 1 kg/L aqueous extract of Astragalus membranaceus 5 mL/kg·dig 6 times a week for 12 weeks. Proximal non-decalcified bone slice measurement. RESULTS: Bone formation and bone resorption increased in ovariectomized rats, but bone resorption was greater than bone formation, bone loss (%Tb.Ar-68%); Astragalus membranaceus extract and DES were effective in preventing ovariectomized rats. Bone loss has similar effects (%Tb.Ar +122% and +85%, respectively, compared with the ovariectomized group, P>0.05 between the two treatment groups), but the mechanism of action is different. Astragalus membranaceus extract only inhibited bone resorption after ovariectomy, while DES inhibited bone resorption and bone formation at the same time, but mainly inhibited bone resorption.