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[目的]比较肝动脉栓塞化疗(TACE)联合射频消融(RFA)和单纯TACE治疗在原发性肝癌患者中的临床疗效。[方法]选取2012年3月~2014年10月我院收治的原发性肝癌患者96例,采用遵循患者意愿和随机法结合的方式,分为对照组和观察组各48例。对照组单纯TACE治疗,观察组TACE联合RFA治疗。[结果](1)2组患者治疗后甲胎蛋白水平降低,且观察组优于对照组,差异有统计学意义(P<0.01)。2组患者治疗后卡氏评分均有提高,且观察组优于对照组,差异有统计学意义(P<0.05)。2组患者治疗有效率观察组66.72%,对照组41.67%,二者比较差异有统计学意义(P<0.05)。2组患者治疗后生存时间12个月和24个月观察组均优于对照组,差异有统计学意义(P<0.05)。(2)危险性分析:2组均发现严重不良反应,主要表现为发热、疼痛、胃肠消化道反应等,对症治理后1周内基本恢复到正常水平。[结论]TACE+RFA联合治疗原发性肝癌效果优于单一使用TACE治疗,可改善患者生活质量,提高治疗有效率,延长患者生存时间,安全可靠。
[Objective] To compare the clinical efficacy of hepatic arterial chemoembolization (TACE) with radiofrequency ablation (RFA) and simple TACE in patients with primary liver cancer. [Methods] A total of 96 patients with primary hepatocellular carcinoma who were treated in our hospital from March 2012 to October 2014 were selected and divided into control group and observation group of 48 patients according to their willingness and random method. Control group only TACE treatment, observation group TACE combined with RFA treatment. [Results] (1) The level of alpha-fetoprotein in the two groups decreased after treatment, and the observation group was superior to the control group, the difference was statistically significant (P <0.01). After treatment, the Karnofsky scores of both groups were improved, and the observation group was better than the control group, the difference was statistically significant (P <0.05). 66.72% of patients in treatment group and 41.67% of control group showed statistically significant difference (P <0.05). The survival time of the two groups after treatment was 12 months and 24 months, the observation group were better than the control group, the difference was statistically significant (P <0.05). (2) Risk analysis: Two groups were found to have serious adverse reactions, mainly manifested as fever, pain, gastrointestinal gastrointestinal reactions, etc., which returned to normal within 1 week after symptomatic treatment. [Conclusion] TACE + RFA combined treatment of primary liver cancer better than single use of TACE treatment can improve the quality of life of patients and improve the treatment efficiency, extend the survival time of patients, safe and reliable.