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阴道节育环(CVR)是一种释放甾体激素的阴道环,在临床上①能提供比口服避孕药(OC)更恒定的体内甾体激素浓度,②不需要经常找医生就诊,③其使用有效率及持续率是可接受的。阴道环中的甾体激素能被阴道迅速吸收进入血液,装在二甲聚硅氧烷器内的甾体激素能被长期释放而不产生局部不适或明显的全身或局部副反应。本文复习了CVR 的发展史,着重讨论了美国人口委员会所设计的 CVR,概述目前对其临床及代谢的研究。W-HO 所设计的只含左旋18甲基炔诺酮(LNG)的阴道环,其释放速率约20μg/日。
Vaginal birth control ring (CVR) is a release of steroid hormone vaginal ring, clinically ① can provide more constant than the oral contraceptives (OC) in vivo steroid hormone concentration, ② do not often need to find a doctor, ③ its use Efficiency and continuity are acceptable. The steroid hormones in the vaginal rings are rapidly absorbed into the vagina by the vagina and the steroid hormones contained in the dimethicone can be released for a long period of time without causing local discomfort or significant systemic or local side effects. This article reviews the history of CVR, focusing on CVRs designed by the U.S. Population Commission, outlining current clinical and metabolic studies. W-HO is designed with a vaginal ring containing only levonorgestrel 18 (LNG) at a release rate of about 20 μg / day.