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目的探讨山莨菪碱(654-2)在促进产程中的作用。方法选取2004年9月至2006年10月期间入住我院初产妇,随机分为山莨菪碱治疗组150例,安定治疗组150例,对照组100例。山莨菪碱组给予静脉推注654-210mg,安定组给予静脉推注安定10mg,对照组不推注任何药物。结果第二产程山莨菪碱组低于安定组(P<0.05),剖宫产率654-2组与安定组间P>0.05,差异无显著性,654-2组与对照组、安定组与对照组间剖宫产率差异具有显著性;产后出血率、新生儿窒息率654-2组和安定组与对照组间P均大于0.05,差异无显著性。结论应用654-2可达到与安定一样的促进第一产程进展的作用,对第二产程也有促进作用,且不增加新生儿窒息率和产后出血率,是一种安全有效的促进产程进展的方法。
Objective To investigate the role of anisodamine (654-2) in promoting labor. Methods A total of 150 primiparous women admitted to our hospital from September 2004 to October 2006 were randomly divided into ananisodamine treatment group (150 cases), diazepam treatment group (150 cases) and control group (100 cases). Anisodamine group was given intravenous injection of 654-210mg, the stability of the group given intravenous bolus stability 10mg, the control group did not push any drugs. Results Anisodamine in the second stage of labor was lower than that in the stable group (P <0.05). There was no significant difference in the incidence of cesarean section between the 654-2 group and the diazepam group. There was no significant difference between the 654-2 group and the control group, The difference of cesarean section rate between the control group was significant. The incidence of postpartum hemorrhage rate, neonatal asphyxia rate 654-2 group and the stability group and the control group P were greater than 0.05, the difference was not significant. Conclusions The application of 654-2 can achieve the same effect of promoting the progress of the first stage of labor as diazepam and also promote the second stage of labor without increasing the rate of neonatal asphyxia and postpartum hemorrhage, which is a safe and effective method to promote the progress of the labor process .