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本文评价了免疫调节子 imiquimod(咪唑喹啉类似物 )对减少和延缓原发 2型单纯疱疹病毒 ( HSV- 2 )生殖道感染豚鼠模型复发的效果。 将 0 .1 ml HSV- 2 ( 5× 1 0 5pfu)接种于 350～ 450 g雌性豚鼠阴道内以建立原发生殖道感染模型 ,待豚鼠的原发疾病于第 1 5天恢复后将其随机
This article evaluated the effect of the immunomodulator imiquimod (imidazoquinoline analogue) on reducing and delaying the relapse of guinea pig models of primary herpes simplex virus type 2 (HSV-2) infections in the reproductive tract. A primary reproductive tract infection model was established by inoculation of 0.1 ml of HSV-2 (5 × 10 5 pfu) in the vagina of 350-450 g female guinea pigs. After the primary disease of guinea pigs was recovered on day 15, they were randomized