论文部分内容阅读
多发性骨髓瘤(MM)是来源于浆细胞克隆性增殖的血液系统恶性肿瘤。骨髓瘤细胞可分泌大量单克隆免疫球蛋白或其片段(M蛋白),临床上常表现贫血、骨痛、溶骨性破坏、肾功能损害、反复感染等,目前仍无法治愈。初诊的MM患者中,20%~28.2%存在肾功能损害(renal impairment,RI)[血清肌酐水平>177μmol/L或>2 mg/dl,或估算肾小球滤过率(eGFR)≤50
Multiple myeloma (MM) is a hematological malignancy derived from clonal multiplication of plasma cells. Myeloma cells can secrete a large number of monoclonal immunoglobulin or its fragment (M protein), clinical manifestations of anemia, bone pain, osteolytic destruction, renal dysfunction, repeated infections, is still incurable. Among the newly diagnosed MM patients, renal impairment (RI) was present in 20% to 28.2% [serum creatinine level> 177 μmol / L or> 2 mg / dl, or estimated glomerular filtration rate (eGFR) ≤50