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FLT3属于Ⅲ型受体酪氨酸激酶家族成员之一,研究表明,其在正常造血及免疫系统的发育中起重要调节作用。FLT3基因突变常见有两种,即内串联复制和点突变。FLT3在急性髓细胞白血病中有过度表达,FLT3基因的内部串联重复(FLT3-ITD)是急性髓细胞白血病最常见的基因异常。FLT3还可作为白血病基因诊断及微小残留病灶的检测标志。本文就FLT3及其突变与白血病的发生、发展及预后的关系予以综述。
FLT3 is a member of the type III receptor tyrosine kinase family and studies have shown that it plays an important regulatory role in normal hematopoiesis and immune system development. There are two common FLT3 gene mutations, namely in-tandem replication and point mutations. FLT3 is overexpressed in acute myeloid leukemia and the FLT3 gene internal tandem repeat (FLT3-ITD) is the most common genetic abnormality in acute myeloid leukemia. FLT3 can also be used as a leukemia genetic diagnosis and detection of residual small lesions mark. This article reviews the relationship between FLT3 and its mutations and the occurrence, development and prognosis of leukemia.