缺血/再灌注损伤时丝裂原活化蛋白激酶信号转导通路的变化

• 作 者: 蔡琪 李晓玫 王海燕
• 机 构: 北京医科大学第一医院肾内科暨肾脏病研究所!北京100034,北京医科大学第一医院肾内科暨肾脏病研究所!北京100034,北京医科大学第一医院肾内科暨肾脏病研究所!北京100034
• 出 处: 中国病理生理杂志
• 发表日期: 2000年12期
• 关键词: 局部缺血 再灌注损伤 有丝分裂原 信号转导 心肌缺血预处理 心肌细胞 心脏缺血 离体心脏 大鼠离体 氧化应激

Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), c-Jun NH2-terminal kinases (JNKs) and p38 MAPK, play an important role in transducting environmental stimuli to the transcriptional machinery in the nucleus in mammalian cells by virtue of their ability to phosphorylate and regulate the activity of various transcription factors. It was recently found that the changes in activity of MAPKs occurred during ischemia/reperfusion, but the biological significance of the changes was still controversial.

Mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs), c-Jun NH2-terminal kinases (JNKs) and p38 MAPK, play an important role in transducting environmental stimuli to the transcriptional machinery in the nucleus in mammalian cells by virtue of their ability to phosphorylate and regulate the activity of various transcription factors. It was recently found that the changes in activity of MAPKs occurred during ischemia / reperfusion, but the biological significance of the changes was still controversial.