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目的探讨雌激素(E_2)、雌激素受体(ER)及孕激素受体(PR)与育龄期妇女子宫内膜息肉(EPs)发病的关系及其在EPs中表达的相关性。方法收集宫腔镜手术中42例子宫内膜息肉患者的子宫内膜息肉(A组)、息肉周围内膜组织(B组)及22例中隔子宫患者正常内膜组织(C组),采用化学发光法及免疫组化法检测E_2、PR及ER的表达。结果 E_2在A组及B组中的表达明显高于C组,差异有统计学意义(P<0.05);E_2在A组中的表达与B组之间相比,差异无统计学意义(P>0.05)。ER在A组中的表达明显高于B组和C组,差异有统计学意义(P<0.01);ER在B组中的表达与C组之间相比,差异有统计学意义(P<0.05)。PR在A组中的表达明显低于B组和C组,差异有统计学意义(P<0.05);PR在B组与C组之间,差异无统计学意义(P>0.05)。结论 E_2、PR及ER可能与育龄期妇女EPs的发病机制有关,协同参与了EPs发生发展的病理变化。
Objective To investigate the relationship between estrogen (E_2), estrogen receptor (ER) and progesterone receptor (PR) and the pathogenesis of endometrial polyps (EPs) in women of childbearing age and its correlation with the expression of EPs. Methods 42 cases of endometrial polyps in hysteroscopic surgery were collected for endometrial polyps (group A), polyps surrounding endometrium (group B) and 22 cases of normal endometrium (group C) Chemiluminescence and immunohistochemistry were used to detect the expression of E_2, PR and ER. Results The expression of E_2 in group A and group B was significantly higher than that in group C (P <0.05). The expression of E 2 in group A was not significantly different from that in group B (P > 0.05). The expression of ER in group A was significantly higher than that in group B and C (P <0.01). The expression of ER in group B was significantly higher than that in group C (P < 0.05). The expression of PR in group A was significantly lower than that in group B and C (P <0.05). There was no significant difference in PR between group B and C (P> 0.05). Conclusions E_2, PR and ER may be related to the pathogenesis of EPs in women of childbearing age and synergistically participate in the pathological changes of EPs.