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目的探讨CYP1A1基因Exon7位点和Msp1位点多态性与宫颈癌遗传易感性的关系。方法 280例老年宫颈癌患者为实验组,280例健康体检者为对照组,用CR-RELP技术和ASA-PCR技术分别检测两组人群Msp1位点和Exon7位点的多态性。结果两组在CYP1A1Ⅱe/Val位点分布上差异有统计学意义(P<0.05);且携带Ⅱe/Val基因型的个体发生宫颈癌的危险是携带Ⅱe/Ⅱe基因型个体的2.473倍。而两组的Msp1基因型多态性分布频率及OR值均无统计学差异(P>0.05)。结论 CYP1A1Exon7基因多态性是发生宫颈癌的危险因素,有可能成为宫颈癌遗传易感标记物。Msp1位点多态性与宫颈癌易感性可能无关。
Objective To investigate the relationship between CYP1A1 gene Exon7 and Msp1 polymorphisms and genetic susceptibility to cervical cancer. Methods Two hundred and eighty elderly patients with cervical cancer were selected as the experimental group and 280 healthy controls as the control group. The polymorphisms of Msp1 and Exon7 were detected by CR-RELP and ASA-PCR respectively. Results There was significant difference in the distribution of CYP1A1Ⅱe / Val between the two groups (P <0.05). The risk of developing cervical cancer in individuals carrying Ⅱe / Val genotype was 2.473 times higher than that of individuals carrying Ⅱe / Ⅱe genotype. However, there was no significant difference in the distribution frequency and OR between Msp1 genotypes in both groups (P> 0.05). Conclusion CYP1A1Exon7 gene polymorphism is a risk factor for cervical cancer, cervical cancer may become a genetic susceptibility markers. Msp1 polymorphism may not be related to cervical cancer susceptibility.