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应用ELISA法和紫外法测定支气管哮喘患者发作期与缓解期血浆因子Ⅷ相关抗原(vWF)和血清血管紧张素转化酶(ACE)水平。结果示哮喘发作组vWF及ACE各为72.1±58.3％及22.9±6.9U;缓解组各为68.8±42.1％及23.2±7.9U;显著低于健康对照组[(117.1±50.3)％及31.3±9.3U,P<0.01]。结合肺功能指标,探讨了vWF和ACE降低的机制及其临床意义。
Serum level of factor Ⅷ related antigen (vWF) and serum level of angiotensin converting enzyme (ACE) in patients with bronchial asthma were measured by ELISA and UV. The results showed that vWF and ACE were 72.1 ± 58.3% and 22.9 ± 6.9U in asthma attack group and 68.8 ± 42.1% and 23.2 ± 7.9U in remission group, which were significantly lower than those in healthy control group (117.1 ± 50.3% vs 31.3 ± 9.3U, P <0.01]. Combined with pulmonary function, the mechanisms of vWF and ACE reduction and their clinical significance were discussed.