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目的:通过检测各类冠心病患者及健康人血清中含血小板凝血酶敏感蛋白的解聚蛋白样金属蛋白酶(ADAMTS)-1的水平,探讨ADAMTS-1水平测定在预测急性冠状动脉综合征(ACS)发生的价值。方法:选择40例急性心肌梗死(AMI)患者,50例不稳定型心绞痛(UAP)患者,40例稳定型心绞痛(SAP)患者,32例健康人,采集临床资料,取外周血,使用ELISA法检测血浆ADAMTS-1水平。结果:ADAMTS-1水平在冠心病组(100.71±37.06)μg/L显著高于对照组(47.04±11.79)μg/L,P<0.05。ADAMTS-1在SAP组(69.33±15.87)μg/L,UAP组(93.43±21.36)μg/L,AMI组(141.18±31.01)μg/L,显示ADAMTS-1水平有随冠心病临床症状的加重而增高的趋势,P<0.05。经多元logistic回归分析后结果显示,在所有入选者中(162例)及在冠心病组(130例)中,ADAMATS-1均与ACS独立相关。经ROC曲线分析,超敏C反应蛋白(HS-CRP)曲线下面积为92.9%(95%CI:88.6%～97.1%),ADAMTS-1曲线下面积为94.0%(95%CI:90.7%～97.3%)。提示AD-AMTS-1在预测ACS的发生方面不劣于甚至略优于HS-CRP。结论:ADAMTS-1可作为预测ACS发生的指标之一。
OBJECTIVE: To investigate the level of ADAMTS-1 in serum of patients with coronary heart disease (CHD) and healthy people with thromboplastin-sensitive protein (PCB), and to investigate the role of ADAMTS-1 in the prediction of acute coronary syndrome ) The value of happening. Methods: Forty patients with acute myocardial infarction (AMI), 50 patients with unstable angina pectoris (UAP), 40 patients with stable angina pectoris (SAP) and 32 healthy individuals were enrolled in this study. Clinical data were collected and peripheral blood was collected. Plasma levels of ADAMTS-1 were measured. Results: The level of ADAMTS-1 in CHD group (100.71 ± 37.06) μg / L was significantly higher than that in control group (47.04 ± 11.79) μg / L, P <0.05. ADAMTS-1 in the SAP group (69.33 ± 15.87) μg / L, UAP group (93.43 ± 21.36) μg / L, AMI group (141.18 ± 31.01) μg / L, indicating that ADAMTS-1 levels increased with the clinical symptoms of coronary heart disease The increasing trend, P <0.05. After multivariate logistic regression analysis, ADAMATS-1 was independently associated with ACS in all enrolled patients (162 patients) and in CHD patients (130 patients). The ROC curve analysis showed that the area under the curve of HS-CRP was 92.9% (95% CI: 88.6% -97.1%) and the area under the ADAMTS-1 curve was 94.0% (95% CI: 90.7% 97.3%). It is suggested that AD-AMTS-1 is not worse than even slightly better than HS-CRP in predicting the occurrence of ACS. Conclusion: ADAMTS-1 can be used as a predictor of ACS.