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应用自己合成的脑钠素(BNP)和脑钠素类似物(BNP-A),研究了它们的生物活性。研究结果如下:(1)在低渗葡萄糖溶液极度扩增大鼠血容量时,脑室内注入BNP仍有明显利钠作用,但对输入5％或10％葡萄糖溶液的大鼠无明显的利钠利尿的累加效应;(2)60分钟内静脉滴入BNP或BNP-A能明显降低自发性高血压大鼠血管紧张素I和醛固酮浓度,但一次大剂量给予BNP却使血管紧张素I浓度明显增加,醛固酮浓度正常。这可能是激素分泌抑制后的反跳现象;(3)体外实验表明,BNP扩张血管的效果不如降钙素基因相关肽(CGRP),但在体内增加局部脑血流的效果与CGRP相仿。实验结果表明,BNP是一种调节水盐代谢和局部脑血流的重要多肽。
Their biological activities were studied using their own synthesized brain natriuretic peptide (BNP) and brain natriuretic peptide (BNP-A). The results were as follows: (1) When the blood volume of rat in hypertonic glucose solution was extremely increased, BNP still showed significant sodium infusion in rats, but no significant sodium infusion was found in rats fed 5% or 10% glucose solution Diuretic cumulative effect; (2) intravenous infusion of BNP or BNP-A within 60 minutes can significantly reduce the spontaneous hypertensive rats angiotensin I and aldosterone concentration, but a large dose of BNP but angiotensin I concentration was significantly Increase, normal aldosterone concentration. This may be the rebound phenomenon after the inhibition of hormone secretion. (3) In vitro experiments showed that BNP dilate blood vessels is not as good as CGRP, but the effect of increasing local cerebral blood flow in vivo is similar to that of CGRP. The experimental results show that BNP is an important polypeptide that regulates water and salt metabolism and local cerebral blood flow.