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茶多酚可以作用于动脉粥样硬化形成和进展过程的各个环节,主要是通过抑制Cu~(2+)诱导的、内皮细胞和巨噬细胞介导的低密度脂蛋白中胆固醇的氧化作用,从而延缓动脉粥样硬化的形成。其可能机制是茶多酚清除自由基如超氧化阴离子、羟自由基和脂质过氧化物,打断链式反应:螫合并去除铁离子和铜离子;抑制巨噬细胞产生和释放过氧化氢;保护脂蛋白中的α-维生素E,促进其再生;抑制多种酶包括环氧酶、脂质氧化酶和超氧化物歧化酶;抑制炎症反应等。
Tea polyphenols can act on all aspects of the formation and progression of atherosclerosis, mainly by inhibiting Cu~(2+)-induced endothelial cell and macrophage-mediated oxidation of cholesterol in low-density lipoproteins. This delays the formation of atherosclerosis. Its possible mechanism is that tea polyphenols scavenge free radicals such as superoxide anions, hydroxyl radicals, and lipid peroxides, breaking the chain reaction: helium combined to remove iron and copper ions; inhibit macrophage production and release of hydrogen peroxide Protect alpha-tocopherol in lipoproteins and promote their regeneration; inhibit a variety of enzymes including cyclooxygenases, lipid oxidases, and superoxide dismutase; inhibit inflammatory responses.