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目的:探讨药物防治丙戊酸钠肝损害的临床疗效及安全性。方法:选择130例癫痫患儿,随机分为三组,均口服丙戊酸钠,治疗组(n=44)应用维生素E+辅酶Q10,对照组(n=45)加用复方甘草酸苷片(美能)+维生素C,空白组(n=41)仅口服丙戊酸钠。结果:治疗组与其他两组对比差异均有统计学意义(P<0.01)。结论:维生素E+辅酶Q10防治丙戊酸钠肝损害疗效显著,安全性高。
Objective: To investigate the clinical efficacy and safety of drugs in preventing and treating valproic acid liver injury. Methods: A total of 130 children with epilepsy were enrolled in this study. All patients were randomly divided into three groups: oral sodium valproate (n = 44), vitamin E + coenzyme Q10 (n = 45) and compound glycyrrhizin Beauty can) + vitamin C, blank group (n = 41) only oral sodium valproate. Results: The difference between the treatment group and the other two groups was statistically significant (P <0.01). Conclusion: The efficacy and safety of vitamin E + CoQ10 against sodium valproate in liver injury are significant.