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目的探讨人乳头瘤病毒(HPV)在宫颈上皮内瘤变(CIN)中的表达,以及它们之间的相互关系,通过HPV检测尽早筛查出患宫颈上皮内瘤变的高危人群。并对术前术后随访中高危型HPV变化与病变残留复发情况进行动态观察及分析,以便采取有效的预防和治疗措施。方法对169例宫颈病变患者采用杂交捕获技术对HPV进行筛查,并通过阴道镜对可疑病灶多点活检。结果 169例宫颈病变患者中HPV阳性者68例(40.2%),阴性者101例(59.8%);病理活检慢性炎症73例(43.2%),宫颈癌及癌前病变96例(56.8%);HPV阳性患者的宫颈癌及癌前病变率为70.8%(68/96)。结论检测高危型HPV不仅可以发现现行的宫颈疾病患者,还可以发现存在高危风险的人群,是监测CIN的一个重要的指标;通过检测高危型HPV,有针对性地进行活组织病理检查,可有效地指导临床,有助于探讨CIN的发病机制。
Objective To investigate the expression of human papillomavirus (HPV) in cervical intraepithelial neoplasia (CIN) and the correlation between them, and to screen the high risk group with cervical intraepithelial neoplasia as soon as possible by HPV test. We also observed and analyzed the changes of high risk HPV and residual disease recurrence before and after surgery in order to take effective preventive and therapeutic measures. Methods 169 cases of cervical lesions using hybridization capture HPV screening technology, and colposcopy on suspicious lesions multi-biopsy. Results There were 68 cases (40.2%) of HPV positive in 169 cases of cervical lesions, 101 cases (59.8%) of negative cases, 73 cases (43.2%) of chronic inflammation in pathological biopsy and 96 cases (56.8%) of cervical cancer and precancerous lesions. The incidence of cervical cancer and precancerous lesions in HPV-positive patients was 70.8% (68/96). Conclusion Detection of high-risk HPV can not only detect the current cervical disease patients, but also can be found in high-risk groups of people is an important indicator of monitoring CIN; by detecting high-risk HPV, targeted biopsy can be effective To guide the clinical, help to explore the pathogenesis of CIN.