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亚硝胺是目前公认的化学致癌物,它可在体内酸性环境中由仲胺或酰胺与HNO_2、NOCl、N_2O_3N_2O_4、NOBF_4及NO-3-硝基卡唑等形成,某些叔胺亦可与亚硝酸盐反应合成亚硝胺。实验表明,氨基比林(AP)与NaNO_2可在大鼠体内合成二甲基亚硝胺(DMN),
Nitrosamines are currently recognized as chemical carcinogens and can be formed from secondary amines or amides with HNO_2, NOCl, N_2O_3N_2O_4, NOBF_4 and NO_3-nitrocarbazoles in the acidic environment in vivo. Some tertiary amines can also form with Nitrite synthesis of nitrosamines. Experiments show that aminopyrine (AP) and NaNO 2 can be synthesized in rats dimethylnitrosamine (DMN)