论文部分内容阅读
目的:探讨可溶性血管细胞粘附分子-1(sVCAM-1)及肿瘤坏死因子-α(TNF-α)在妊娠肝内胆汁淤积症(ICP)发病中的作用。方法:测定49例孕妇血清中sVCAM-1、TNF-α水平,其中正常妊娠组15例,ICP组34例,包括轻型14例,重型20例。用酶联免疫吸附法(ELISA)测定sVCAM-1,用放射免疫法(R IA)测定TNF-α。结果:重型ICP患者血中sVCAM-1、TNF-α水平均显著高于正常妊娠组(P<0.01),轻型ICP患者与正常妊娠组相比,虽无统计学差异,但有升高趋势,ICP组产后各项指标下降与正常妊娠组无显著性差异(P>0.05)。TNF-α与sVCAM-1呈正相关(r=0.532,P<0.01)。结论:ICP患者粘附分子的异常表达可能是ICP发病机制的一个重要环节;TNF-α可诱导sVCAM-1的表达。
Objective: To investigate the role of soluble vascular cell adhesion molecule-1 (sVCAM-1) and tumor necrosis factor-α (TNF-α) in the pathogenesis of intrahepatic cholestasis of pregnancy (ICP). Methods: Serum levels of sVCAM-1 and TNF-α were measured in 49 pregnant women. Among them, 15 were normal pregnancy group and 34 were ICP group, including 14 cases of light and 20 cases of severe. SVCAM-1 was determined by enzyme-linked immunosorbent assay (ELISA) and TNF-α by radioimmunoassay (RIA). Results: The levels of sVCAM-1 and TNF-α in blood in severe ICP patients were significantly higher than those in normal pregnant women (P <0.01). There was no significant difference between the mild ICP patients and normal pregnant women, There was no significant difference between the ICP group after birth and normal pregnancy (P> 0.05). TNF-α was positively correlated with sVCAM-1 (r = 0.532, P <0.01). Conclusion: Abnormal expression of adhesion molecules in ICP may be an important part of the pathogenesis of ICP. TNF-α may induce the expression of sVCAM-1.