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脂质过氧化是生物损伤的形式之一,是许多毒物致毒的起点,也可能是致癌、致畸、致突变的环节之一,近年报道,具有致癌性塑料工业原料——氯乙烯,可诱导脂质过氧化,也可改变某些微粒体酶的活性。但氯乙烯对微粒体酶的影响是否与其脂质过氧化作用有关?至今国内外均未见报道。本文通过体外和整体实验,将氯乙烯诱导的脂质过氧化与微粒体酶系的变化结合起来研究,探讨氯乙烯诱导的脂质过氧化对微粒体酶的影响,为研究氯乙烯的中毒机理提供科学依
Lipid peroxidation is one of the forms of biological damage, is the starting point of many poisoning, but also may be one of the carcinogenic, teratogenic and mutagenic links, reported in recent years, with carcinogenic plastic raw materials - vinyl chloride, Inducing lipid peroxidation may also alter the activity of certain microsomal enzymes. However, the impact of vinyl chloride microsomal enzymes with its lipid peroxidation? No reports have been reported at home and abroad. In this paper, in vitro and in vivo experiments, the vinyl chloride-induced lipid peroxidation and changes in microsomal enzymes combine to study the impact of vinyl chloride-induced lipid peroxidation of microsomal enzymes, in order to study the mechanism of vinyl chloride poisoning Provide scientific basis