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目的探讨子痫前期孕妇的孕周和夜间收缩压负荷对母儿不良事件发生的影响。方法选取2015年1月-2016年3月在济宁医学院附属医院产科诊治的106例子痫前期患者为研究对象,根据是否出现母儿不良妊娠事件分为研究组(发生不良妊娠事件,56例)和对照组(无不良妊娠事件,50例),并采用动态血压仪监测孕妇24 h内的多项血压相关参数。结果研究组的孕周显著低于对照组(P<0.05);与对照组相比,研究组的24 h DBP、24 h SBP、dDBP、dSBP、nDBP、nSBP、dDBPL、dSBPL、nDBPL和nSBPL均显著升高,差异有统计学意义(P<0.05);Logistic回归分析显示,子痫前期孕妇的孕周和夜间收缩压负荷与母儿不良事件的发生有显著相关性(OR=1.37,95%CI:1.21~1.71,P=0.002;OR=1.99,95%CI:1.45~2.16,P=0.000)。结论子痫前期孕妇的孕周和夜间收缩压负荷与母儿不良事件的发生存在相关性,临床上应予以密切监护。
Objective To investigate the effect of gestational age and nighttime systolic pressure load on the incidence of adverse events in pregnant women and children with preeclampsia. Methods From January 2015 to March 2016, 106 patients with preeclampsia diagnosed and treated in the obstetrics department of Jining Medical College Affiliated Hospital were enrolled in the study group (56 cases of adverse pregnancy events) according to whether there was any adverse pregnancy. And control group (no adverse pregnancy events, 50 cases), and the use of ambulatory blood pressure monitor blood pressure within 24 hours of pregnancy related parameters. Results The gestational age of the study group was significantly lower than that of the control group (P <0.05). Compared with the control group, the 24 h DBP, 24 h SBP, dDBP, dSBP, nDBP, nSBP, dDBPL, dSBPL, nDBPL and nSBPL (P <0.05). Logistic regression analysis showed that gestational age and nocturnal systolic pressure load in pregnant women with preeclampsia were significantly correlated with adverse events (OR = 1.37, 95% CI: 1.21-1.71, P = 0.002; OR = 1.99, 95% CI: 1.45-2.16, P = 0.000). Conclusion Pregnant women with preeclampsia and gestational age and night systolic blood pressure load and adverse events occurred in maternal and childrelated to the existence of clinics should be closely monitored.