论文部分内容阅读
目的:观察急性心肌梗死(AMI)合并心力衰竭(心衰)患者血清白细胞介素(IL)-6、10对心功能的影响。方法:选择AMI患者(AMI组)30例于发病后24 h检测血清IL-6、IL-10。在心肌梗死后2周内观察心功能,心脏超声心动图检查测定左室射血分数(EF)、左室短轴缩短率(FS)、等容舒张期时间(IVRT)。结果:AMI合并心衰组血清IL-6水平及IL-6/IL-10比值高于未合并心衰组,分别是IL-6:[(306.35±131.32)∶(198.59±52.08)ng/L,P<0.05]、IL-6/IL-10比值:[(18.18±12.66)∶(11.49±7.47),P<0.05]。相关分析:IL-6、IL-10与IVRT呈正相关(r=0.624、r=0.297,P<0.05),与EF(r=-0.559、r=-0.364,P<0.05)、FS(r=-0.453、r=-0.324,P<0.05)呈负相关,IL-6与心功能分级呈正相关(r=0.540、r=0.0.085,P<0.05)。结论:AMI合并心衰时IL-6水平增高更为显著,IL-6/IL-10比值增大。
Objective: To observe the effects of serum interleukin (IL) -6,10 in patients with acute myocardial infarction (AMI) complicated with heart failure (heart failure) on cardiac function. Methods: Serum IL-6 and IL-10 levels were measured in 30 AMI patients (AMI group) at 24 h after onset. Cardiac function was observed within 2 weeks after myocardial infarction. Left ventricular ejection fraction (EF), left ventricular fractional shortening (FS) and isovolumic diastolic time (IVRT) were measured by echocardiography. Results: The serum levels of IL-6 and IL-6 / IL-10 in patients with AMI complicated with heart failure were significantly higher than those without heart failure (IL-6: 306.35 ± 131.32, 198.59 ± 52.08, , P <0.05], IL-6 / IL-10 ratio: [(18.18 ± 12.66): (11.49 ± 7.47), P <0.05]. Correlation analysis showed that IL-6 and IL-10 were positively correlated with IVRT (r = 0.624, r = 0.297, P <0.05) -0.453, r = -0.324, P <0.05). There was a positive correlation between IL-6 and cardiac function classification (r = 0.540, r = 0.0.085, P <0.05). CONCLUSION: When AMI is combined with heart failure, the level of IL-6 is increased more significantly and the ratio of IL-6 / IL-10 is increased.