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Cibenzoline 为咪唑啉的衍生物,是一种新的抗心律失常药。该药口服后可完全吸收,主要由肾脏排泄,在健康人中的半衰期为4.5小时,急性心肌梗塞病人则为7.3小时。作者进一步研究 Cibenzoli-ne 对可用实验方法复制的阵发性室上性心动过速患者的电生理效应,抗心律失常作用及药物动力学。方法:折返性室上性心动过速反复发作的患者12例(男2,女10),年龄18～63岁。其中5例折返位于房室结内,1例折返位于心房内。窦性心律时表现为 W-P-W 综合征4例(A 型3例,B 型1例),而给予顺序刺激则产生旁路环行心动过速。左侧附
Cibenzoline, a derivative of imidazoline, is a new antiarrhythmic drug. The drug is completely absorbed orally and is mainly excreted by the kidneys, with a half-life of 4.5 hours in healthy individuals and 7.3 hours in acute myocardial infarction patients. The authors further investigated the electrophysiological effects, anti-arrhythmic effects, and pharmacokinetics of Cibenzoli-ne in patients with paroxysmal supraventricular tachycardia that replicate with available experimental methods. Methods: Twelve patients (male 2, female 10) with recurrence of supraventricular supraventricular tachycardia were aged 18-63 years. Among them, 5 cases were located in atrioventricular node, and 1 case was located in the atria. Sinus rhythm showed W-P-W syndrome in 4 cases (type A in 3 cases, type B in 1 case), while giving sequential stimulation produces a bypass tachycardia. Left side attached