论文部分内容阅读
目的:研究卡前列素氨丁三醇减少高危孕妇剖腹产后出血和输血的临床效果。方法:选择行剖腹产手术的高危产妇106例,随机分为卡前列素氨丁三醇组(观察组)53例和对照组53例。对照组宫体注射缩宫素20U并舌下含服米索前列醇片0.2mg和静脉注射10%葡萄糖酸钙注射液10ml;观察组宫体注射缩宫素20U及卡前列素氨丁三醇250μg。比较2组产妇产后2h、24h出血量、产后出血率、止血时间、输血率、子宫切除率、有效率及不良反应。结果:(1)观察组产后2h、24h出血量及产后出血率均显著低于对照组,差异均有统计学意义(t=9.736,t=6.730,χ~2=6.023,P均<0.05)。(2)观察组产后止血时间、输血率均低于对照组,差异均有统计学意义(t=12.304,t=5.671,P均<0.05)。2组子宫切除率差异无统计学意义(χ~2=1.369,P>0.05)。(3)观察组总有效率(94.34%)显著高于对照组(73.59%),差异有统计学意义(χ~2=8.461,P<0.05)。2组不良反应发生率比较,差异无统计学意义(χ~2=0.103,P>0.05)。结论:对有产后出血高危因素的产妇,宫体注射卡前列素氨丁三醇能明显减少产后出血量、显著降低产后出血率和输血率。
Objective: To study the clinical effect of carboprost trometamol in reducing post-cesarean section bleeding and transfusion in high-risk pregnant women. Methods: A total of 106 high-risk maternal women undergoing caesarean section were randomly divided into carboprodno trometamol group (observation group) and control group (n = 53). In the control group, 20U of oxytocin and 10 mg of misoprostol and 10% of calcium gluconate were injected subcutaneously into the uterine cavity of the control group. Oxytocin 20U and carboprost tromethamine 250 μg. The 2 groups of postpartum 2h, 24h bleeding, postpartum hemorrhage, bleeding time, blood transfusion, hysterectomy, effective rate and adverse reactions were compared between the two groups. Results: (1) The amount of bleeding and the rate of postpartum hemorrhage in observation group at 2h and 24h postpartum were significantly lower than those in control group (t = 9.736, t = 6.730, χ ~ 2 = 6.023, P <0.05) . (2) The bleeding time and blood transfusion rate in the observation group were all lower than those in the control group (t = 12.304, t = 5.671, P <0.05). There was no significant difference in hysterectomy rates between the two groups (χ ~ 2 = 1.369, P> 0.05). (3) The total effective rate (94.34%) in the observation group was significantly higher than that in the control group (73.59%), the difference was statistically significant (χ ~ 2 = 8.461, P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ ~ 2 = 0.103, P> 0.05). Conclusion: For women who have high risk factors for postpartum hemorrhage, carboprost tromethamine can significantly reduce the amount of postpartum hemorrhage and significantly reduce the rate of postpartum hemorrhage and blood transfusion.