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目的 :探讨胃粘膜细胞内叶酸水平的变化。方法 :胃镜取活组织经病理证实为胃癌 3 0例、胃癌癌前状态 3 8例 (胃粘膜结肠型肠上皮化生 1 8例 ,中度非典型增生 2 0例 )、正常胃粘膜 3 0例 ,测定以上组织中叶酸水平。结果 :胃癌组织细胞内叶酸水平明显低于正常胃粘膜细胞和癌前状态细胞 ,而癌前状态细胞内叶酸水平又明显低于正常胃粘膜细胞 ,胃粘膜结肠型肠上皮化生和中度非典型增生细胞内叶酸水平无明显差异。结论 :胃粘膜细胞内叶酸水平从正常胃粘膜到胃癌癌前状态及胃癌呈依次性递减 ,各组之间差异有统计学意义 ,胃粘膜结肠型肠上皮化生和中度非典型增生细胞内叶酸水平无明显差异
Objective: To investigate the changes of folic acid in gastric mucosal cells. Methods: Gastroscopic biopsies were confirmed by pathology as 30 cases of gastric cancer, 38 cases of gastric precancerous state (18 cases of gastric mucosal colonic metaplasia, 20 cases of moderate atypical hyperplasia), 30 cases of normal gastric mucosa Example, determination of folic acid levels in the above tissues. Results: The level of folic acid in gastric cancer tissues was significantly lower than that in normal gastric mucosa cells and precancerous cells, whereas the intracellular folic acid levels in pre-cancerous state were significantly lower than those in normal gastric mucosa, gastric mucosa and intestinal metaplasia There was no significant difference in folic acid level in hyperplasia cells. CONCLUSION: The level of folate in gastric mucosa is decreased from normal gastric mucosa to precancerous gastric cancer and gastric cancer, with significant difference between the groups. In gastric mucosa, colonic metaplasia and moderate atypical hyperplasia Folic acid levels no significant difference