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目的探讨复方甘草酸苷联合护肝片对抗结核药所致轻、中度肝损害的疗效。方法抗结核药所致肝损害87例患者随机被选入2组,治疗组45例,不停抗结核药,在常规保肝治疗的基础上,治疗组以复方甘草酸苷注射液静脉滴注加护肝片口服给药,qd8wK。对照组42例,用常规保肝治疗加护肝片口服给药,qd8wK。结果治疗3周时的血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AsT)水平及总有效率,两组间的差异均有统计学意义(P<0.05或<0.01)。结果表明,复方甘草酸苷注射液联合护肝片对抗结核药所致肝损害的治疗效果较单用护肝片更为显著。
Objective To investigate the curative effect of compound glycyrrhizin combined with Hugan tablet on mild and moderate hepatic injury induced by antituberculosis drugs. Methods Eighty-seven patients with liver damage caused by anti-TB drugs were randomly divided into two groups. The treatment group consisted of 45 patients with anti-tuberculosis drugs. On the basis of routine hepatoprotective therapy, the treatment group received intravenous compound glycyrrhizin injection Plus liver tablets oral administration, qd8wK. The control group of 42 cases, with conventional liver protection plus liver tablets oral administration, qd8wK. Results Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AsT) and total effective rate at 3 weeks after treatment were significantly different between the two groups (P <0.05 or <0.01) ). The results showed that compound glycyrrhizin injection Hugan tablet anti-tuberculosis drug-induced liver damage than the single treatment of liver tablets is more significant.