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目的:探讨血管内皮生长因子(VEGF)的表达与肾细胞癌(RCC)并发静脉癌栓(VTT)的关系。方法:采用免疫组织化学MaxVision~(TM)快捷法检测57例并发或未并发VTT的RCC组织和10例远离肿瘤的正常肾组织中VEGF的表达状况。实验分为三组,A组:并发VTT的RCC组织27例;B组:未并发VTT的RCC组织30例;C组:远离肿瘤的正常肾组织10例。结果:VEGF在三组中的阳性表达率分别为81.5%、63.3%和20.0%,其中A组和C组差异有统计学意义(P<0.01),A组和B组差异无统计学意义(P>0.05),B组和C组差异有统计学意义(P<0.05)。结论:VEGF的异常表达可能在RCC并发VTT的形成中发挥重要作用,以抑制VEGF蛋白及其受体作用的靶向治疗药物在RCC并发VTT的治疗中应有良好效果。
Objective: To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and renal cell carcinoma (RCC) complicated with venous thrombosis (VTT). Methods: The expression of VEGF in 57 cases of RCC tissues with and without VTT and 10 cases of normal renal tissues far away from the tumor were detected by immunohistochemistry MaxVisionTM. The experiment was divided into three groups: group A: 27 cases of RCC with VTT; group B: 30 cases of RCC without VTT; group C: 10 cases of normal renal tissue far from tumor. Results: The positive rates of VEGF expression in the three groups were 81.5%, 63.3% and 20.0%, respectively. There was significant difference between group A and group C (P <0.01), but there was no significant difference between group A and group B P> 0.05). There was significant difference between group B and group C (P <0.05). Conclusion: The abnormal expression of VEGF may play an important role in the formation of RCC complicated with VTT. The targeted therapy that inhibits VEGF protein and its receptor should have good effect in the treatment of RCC complicated with VTT.