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人类阴道粘膜与口腔粘膜具有相似的组织学特征,对水的屏障作用也基本相似。但他们渗透药物的能力是否相同,以及阴道粘膜能否作为合适的药物渗透性研究的实验模型仍未清除。为此,作者研究了这两种组织对17β-雌二醇的渗透能力。 作者选择6个健康的阴道粘膜标本和6个口腔颊粘膜标本,应用流量通过扩散系统研究17β-雌二醇透过这两种组织的能力。 结果发现:17β-雌二醇透过人类颊粘膜的流量略高于透过子宫颈粘膜的流量(约15％),但差异不显著。渗透试验完成后,其上皮变薄,细胞有一定程度的变平。 作者认为:17β-雌二醇透过人类子宫颈粘膜与人
Human vaginal mucosa and oral mucosa have similar histological features, the role of water barrier is also basically similar. However, their ability to penetrate the drug is the same, and the vaginal mucosa as a suitable experimental model of drug permeability studies have not yet cleared. To this end, the authors investigated the ability of these two tissues to penetrate 17β-estradiol. The authors selected six healthy vaginal mucosa specimens and six buccal mucosa specimens to assess the ability of 17β-estradiol to penetrate both tissues through a diffusion system using flow rates. The results showed that the flow rate of 17β-estradiol through the human buccal mucosa was slightly higher than the flow through the cervical mucosa (about 15%), but the difference was not significant. After the penetration test was completed, the epithelium became thinner and the cells became flattened to some extent. The authors believe: 17β-estradiol through the human cervical mucosa and human