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目的研究地特胰岛素联合二甲双胍治疗初诊2型糖尿病(T2DM)的临床疗效,探讨治疗初诊T2DM的最佳药物治疗方案。方法将门诊及住院的初诊T2DM患者88例随机分为地特胰岛素组和联合用药组,各44例。地特胰岛素组给予地特胰岛素治疗,联合用药组给予地特胰岛素联合二甲双胍治疗。治疗半年后,比较两组患者治疗前后糖化血红蛋白(HbA1C)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平及临床疗效。结果与治疗前比较,治疗后两组患者HbA1C、FPG、2 h PG水平均下降,联合用药组下降更明显,差异均有统计学意义(P<0.05)。联合用药组总有效率为88.6%,高于地特胰岛素组(72.7%),差异有统计学意义(χ2=3.76,P<0.05)。结论地特胰岛素联合二甲双胍治疗初诊T2DM疗效显著,值得临床推广应用。
Objective To study the clinical efficacy of detemir plus metformin in the treatment of newly diagnosed type 2 diabetes mellitus (T2DM) and to explore the optimal drug regimen for the treatment of newly diagnosed T2DM. Methods Eighty-eight outpatients and newly diagnosed inpatients with T2DM were randomly divided into insulin detemir group and combination group, 44 cases in each group. The insulin detemir group was treated with detemir and the combination group was given detemir plus metformin. After six months of treatment, the levels of HbA1C, fasting blood glucose (FPG) and 2 h postprandial blood glucose (2 h PG) were compared between the two groups before and after treatment. Results Compared with those before treatment, the levels of HbA1C, FPG and 2 h PG decreased in both groups after treatment, and the combination group decreased more obviously with statistical significance (P <0.05). The total effective rate was 88.6% in the combination group, higher than that in the insulin detemir group (72.7%), the difference was statistically significant (χ2 = 3.76, P <0.05). Conclusion Dextrins combined with metformin treatment of newly diagnosed T2DM significant effect, worthy of clinical application.