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目的:对利奈唑胺应用于结核性脑膜炎临床治疗中的效果及体会进行分析总结。方法:选取62例2015年1月-2017年3月期间在我院接受治疗的结核性脑膜炎患者,并1:1随机分为参照组(给予常规治疗)和实验组(给予利奈唑胺治疗)各31例,对两种治疗方法的效果进行对照研究。结果:就脑脊液压力、白细胞水平以及蛋白定量而言,实验组患者明显低于参照组;就治疗总有效率而言,实验组患者均明显高于参照组[90.32%vs.70.97%],因为P<0.05,组间差异具有统计学意义。结论:利奈唑胺应用于结核性脑膜炎临床治疗中有一定的疗效,对其抗结核作用值得进行深入的研究。
Objective: To analyze the effect and experience of linezolid in the clinical treatment of tuberculous meningitis. Methods: Sixty-two patients with tuberculous meningitis who were treated in our hospital from January 2015 to March 2017 were selected and randomly divided into two groups: the reference group (given conventional therapy) and the experimental group (treated with linezolid ) 31 cases in each, the effect of the two treatment methods for controlled study. Results: The cerebrospinal fluid pressure, leukocyte level and protein quantitation were significantly lower in the experimental group than in the reference group. For the total effective rate, the experimental group was significantly higher than the reference group [90.32% vs.70.97%] because P <0.05, the difference between groups was statistically significant. Conclusion: Linezolid is effective in the clinical treatment of tuberculous meningitis, and its anti-TB effect deserves further study.