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目的:探讨TUVP联合间歇性和持续性雄激素去势对改善晚期前列腺癌患者生活质量和总生存率的影响。方法:随机抽取我院136例晚期前列腺癌患者,将其分为两组,对照组69例,采用TUVP联合持续性雄激素去势治疗,观察组67例,采用TUVP联合间歇性雄激素去势治疗,比较两组治疗3个月后的国际前列腺症状评分、生活质量评分及随访一年后总生存率之间的差异。结果:治疗3个月后,观察组患者在国际前列腺评分、生活质量评分及随访一年后的总生存率分别为1.85±0.48,1.85±0.48,89.55%,明显优于对照组,差异有统计学意义(P<0.05)。结论:对晚期前列腺癌患者来说,TUVP联合间歇性雄激素去势治疗是安全有效的治疗方法,能明显改善患者的临床症状,提高生活质量,提高癌症患者的总生存率。
Objective: To investigate the effect of TUVP combined with intermittent and continuous androgen castration on the quality of life and overall survival in patients with advanced prostate cancer. Methods: One hundred and sixty-six patients with advanced prostate cancer in our hospital were randomly divided into two groups. The control group (n = 69) was treated with TUVP combined with continuous androgen castration. The observation group consisted of 67 patients. TUVP combined with intermittent androgenic castration The differences in the International Prostate Symptom Score, Quality of Life Scores and Total Survival Rates one year after follow-up were compared between the two groups after 3 months of treatment. Results: After 3 months of treatment, the overall survival rate of the observation group was 1.85 ± 0.48, 1.85 ± 0.48 and 89.55% respectively after the international prostate score, quality of life score and year after follow-up, which were significantly better than the control group Significance (P <0.05). Conclusions: TUVP combined with intermittent androgen castration is a safe and effective treatment for advanced prostate cancer patients. It can significantly improve the clinical symptoms, improve the quality of life, and improve the overall survival of cancer patients.