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目的:探讨亚甲基四氢叶酸还原酶(MTHFR) 基因C677T多态性与新疆哈族、汉族食管癌易感性的关系．方法:用PCR-RFLP方法检测食管癌患者178 例(哈萨克族94例,汉族84例)和同一地区无肿瘤病史的正常对照者155例(哈萨克族98例,汉族57例)的MTHFR基因C677T基因型分布．结果:新疆哈族食管癌组中MTHFR C677T 3种基因型CC,CT,TT,所占比例分别是 56．4％,36．2％,7．4％,与新疆汉族食管癌组中的32．9％,40．0％,27．1％相比,存在显著差异(X2=1 5．37,P<0．05);哈族正常对照组分别为58．2％,29．6％,12．2％与汉族正常对照组 22．8％,52．6％,24．6％相比,有显著差异(X2= 18．26,P<0．05)．MTHFR 3种基因型在哈族食管癌组中的分布(CC 56．4％,CT 36．2％and TT 7．4％)与对照组中(CC 22．8％,CT 52．6％and TT 24．6％)相比,无显著差异(X2=1．776,P= 0．412)．在汉族食管癌组与对照组间也无显著差异(X2=2．750,P=0．253)．结论:MTHFR C677T基因多态性分布在新疆哈族、汉族正常对照组间存在民族差异,在食管癌间也存在差异．MTHFR C677T基因多态性可能与新疆哈萨克族与汉族食管癌的易感性无关．
Objective: To investigate the relationship between methylene tetrahydrofolate reductase (MTHFR) gene C677T polymorphism and susceptibility to esophageal cancer in Kazakh and Han populations in Xinjiang. Methods: The MTHFR gene C677T gene was detected by PCR-RFLP in 178 patients with esophageal cancer (94 Kazakhs and 84 Hans) and 155 normal controls (98 Kazakhs and 57 Hans) with no history of oncology in the same area. Type distribution. RESULTS: The proportions of CC, CT, and TT of the three genotypes of MTHFR C677T in Xinjiang Kazakh esophageal cancer group were 56.4%, 36.2%, and 7.4%, respectively, and 32 in Xinjiang Han esophageal cancer group. There was a significant difference ( .2=1 5.37, P<0.05) between .9%, 40.0%, and 27.1%, and 58.2% and 29.6% for the Kazakh normal controls, respectively. 12.2% had a significant difference (22.8%, 52.6%, 24.6%) from the Han normal control group (X2 = 18.26, P<0.05). The distribution of three MTHFR genotypes in the Kazakh esophageal cancer group (CC 56.4%, CT 36.2% and TT 7.4%) and control group (CC 22.8%, CT 52.6% and Compared with TT 24.6%), there was no significant difference (X2=1.776, P=0.412). There was also no significant difference between the Han esophageal cancer group and the control group (X2=2.750, P=0.253). Conclusion: There is a national difference in MTHFR C677T gene polymorphism distribution among Xinjiang Kazakh and Han nationality normal control groups, and there are also differences in esophageal cancer. MTHFR C677T gene polymorphism may not be related to the susceptibility of Xinjiang Kazakh and Han esophageal cancer.