论文部分内容阅读
目的:观察钙泊三醇倍他米松乳膏与卡泊三醇软膏序贯治疗银屑病患者的疗效及安全性.方法:将90例斑块状寻常性银屑病患者随机分为3组,第一组:外用钙泊三醇倍他米松乳膏4周(每日1次)+钙泊三醇倍他米松乳膏与卡泊三醇软膏交替使用2周(均每日1次,2种交替)+卡泊三醇软膏6周(每日1次);第二组:外用钙泊三醇倍他米松软膏6周+卡泊三醇软膏6周(均每日1次);第三组:外用卡泊三醇软膏12周(每日2次).结果:3组患者治疗4、6、12周后银屑病皮损面积和严重程度指数(PASI)评分分别与各组治疗前比较,差异均有统计学意义(P均＜0.05).第一组与第二组疗效均优于第三组,差异均有统计学意义(P均＜0.05),但第一组与第二组疗效比较,差异无统计学意义(P＞0.05).结论:序贯疗法起效快且疗效优,为患者节省医疗开支并减少糖皮质激素的不良反应.“,”Objective:To evaluate the efficacy and safety of sequential use of calcipotriol betamethasone cream and calcipotriol ointment for psoriasis.Methods:Ninety patients with psoriasis were randomly divided into 3 groups.Group 1 was treated with topical calcipotriol betamethasone cream along once daily for 4 weeks+alternate use of calcipotriol betamethasone cream and calcipotriol ointment once daily for 2 weeks + calcipotriol ointment along once daily for 6 weeks.Group 2 was treated with topical calcipotriol betamethasone ointment along once daily for 6 weeks+calcipotriol ointment along once daily for 6 weeks.Group 3 was given topical calcipotriol ointment twice daily for 12 weeks.Results:Treatments markedly improved the severity of clinical symptoms in all 3 groups(P＜0.05 vs.pretreatment for all groups).The efficacies of groups 1 and 2 were superior to that of group 3(groups 1 and 2 vs.group 3,P＜0.05),while groups 1 and 2 exhibited a similar efficacy(P＞0.05).Conclusions:The sequential therapy can rapidly improve psoriasis,lower medical costs,reduce glucocorticoidinduced adverse reactions.