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人体包虫病至今仍主要依靠手术治疗,但有时难以取得满意疗效,甚至还可增加包虫囊肿的播散,故亟待寻求治疗包虫病的有效药物。近年来某些文献报道吡喹酮治疗包虫病取得一定疗效,但实验结果常有所不同,对此尚有待于进行深入研究和探讨。为了了解药物能否进入包虫囊内以及囊内药物浓度高低与疗效有否密切关系,我们结合手术前用药的机会,利用高效液相色谱仪,在国内外首次检测了服用吡喹酮的患者体内
Human echinococcosis is still mainly rely on surgery, but sometimes difficult to obtain satisfactory results, and even increase the disseminated hydatid cysts, it is urgent to seek effective treatment of hydatid disease drugs. In recent years, some literatures reported that praziquantel has achieved certain efficacy in the treatment of echinococcosis, but the experimental results are often different, which remains to be further studied and discussed. In order to understand whether the drug can enter the hydatid cyst and the drug concentration in the cyst is closely related to the efficacy, we combined with the opportunity before surgery, the use of high performance liquid chromatography at home and abroad for the first time in patients taking praziquantel in vivo