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目的探讨肺炎支原体感染患儿细胞免疫功能状态及其临床意义。方法采用ＥＬＩＳＡ双抗体夹心法检测８３例肺炎支原体肺炎患儿血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）水平的变化。结果患儿组ｓＩＬ－２Ｒ水平较正常对照组明显增高（Ｐ＜０．０１），发病时间≥７ｄ者较发病时间＜７ｄ者ｓＩＬ－２Ｒ水平增高更为明显（Ｐ＜０．０１），且发病时间与ｓＩＬ－２Ｒ水平间呈密切正相关（Ｐ＜０．０１）。有肺外并发症患儿ｓＩＬ－２Ｒ水平增高较无肺外并发症者明显（Ｐ＜０．０１）。各年龄组ｓＩＬ－２Ｒ水平无显著差异（Ｐ＞０．０５）。结论肺炎支原体感染可致细胞免疫功能减低，有肺外并发症者更为明显，且随病程延长，细胞免疫抑制加重。
Objective To investigate the cellular immune function in children with Mycoplasma pneumoniae infection and its clinical significance. Methods Serum soluble interleukin-2 receptor (sIL-2R) levels were measured in 83 children with mycoplasma pneumoniae pneumonia by ELISA double antibody sandwich method. Results The level of sIL-2R in children was significantly higher than that in normal controls (P <0.01). The incidence of sIL-2R was significantly increased in patients with onset of disease> 7d (P <0.01) The onset time and sIL-2R levels were closely related (P <0.01). The level of sIL-2R in children with extra-pulmonary complications was significantly higher than those without extra-pulmonary complications (P <0.01). There was no significant difference in sIL-2R level among all age groups (P> 0.05). Conclusions Mycoplasma pneumoniae infection can reduce cellular immune function, with extrapulmonary complications more obvious, and with the prolonged course of cell immune suppression increased.