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目的 探讨钙剂、米索前列醇联合缩宫素对高危孕妇剖宫产后出血的影响.方法 选取2016年1月至2018年1月本溪钢铁(集团)总医院妇产科收治的90例高危孕妇作为研究对象,按用药治疗方案不同分为对照组、试验组,各45例.剖宫产后对照组采用缩宫素干预,试验组给予钙剂、米索前列醇以及缩宫素干预,比较两组产妇干预效果、生命体征指标变化情况、产后24 h血红蛋白(Hb)和红细胞(RBC)下降值及用药后不良反应发生情况.结果 试验组产妇第三产程时间短于对照组,且产后24 h的Hb和RBC下降值均低于对照组,各时段出血量均少于对照组,且产后出血发生率低于对照组,差异均有统计学意义(均P0.05).结论 高危孕妇应用钙剂、米索前列醇联合缩宫素防治剖宫产产后出血效果理想,安全高效,不良反应少.“,”Objective To investigate the effects of calcium, misoprostol and oxytocin on cesarean section postpartum hemorrhage in high-risk pregnant women. Methods A total of 90 high-risk pregnant women admitted to department of obstetrics and gynecology of General Hospital of Benxi Iron and Steel (Group) from January 2016 to January 2018 were selected as the research objects. They were divided into control group and experimental group according to different medication treatment schemes with 45 cases in each group. After cesarean section, the control group was intervened with oxytocin, while the experimental group was intervened with calcium, misoprostol and oxytocin. The effects of intervention, changes of vital signs, decrease of hemoglobin and red blood cell 24 hours after delivery and adverse reactions were compared between the two groups. Results The third stage of labor in the experimental group was shorter than that in the control group, and the decrease of HB and RBC in 24 hours after delivery was lower than that in the control group. The amount of bleeding in each period in experimental group was less than that in the control group, and the incidence of postpartum hemorrhage was lower than that in the control group with statistical significance (P0.05). Conclusion High-risk pregnant women using calcium, misoprostol combined with oxytocin to prevent postpartum hemorrhage in cesarean section is safe, effective, and has few adverse reactions.