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新西兰免78只分成8组。试验组、M组和对照组分别静滴去甲肾上腺素(NE)1毫克/公斤、美索克新明或生理盐水。其余5组在NE之前分别给予酚妥拉明(R组)、心得安(P组)、美多心安(MP组)、育亨宾(Y组)以及(口派)唑嗪(PR组)。以半定量方法分析心肌病理损害程度,并测定心肌中糖酵解中间产物11项以及能量代谢产物。结果发现NE组心肌损害显著(P<0.01);P组、MP组、Y组和M组心肌损害类似于NE组;R组和PR组则较NE组减轻(P<0.01)。NE组和MP组心肌尚有明显的代谢障碍,而R组则较接近正常。提示NE所致心肌损害中α受体,尤其α_1受体起了主要作用。作者等对其发生机理进行讨论,并提出新的假设。
New Zealand exempts 78 only into 8 groups. The experimental group, M group and control group were intravenously norepinephrine (NE) 1 mg / kg, Metoclon or saline. The remaining five groups were given phentolamine (R group), propranolol (P group), metoprolol (MP group), yohimbine (Y group) and (oral) . The degree of myocardial pathological damage was analyzed by semi-quantitative method, and 11 items of myocardial glycolysis intermediate products and energy metabolites were determined. Myocardial damage was found in NE group (P <0.01). Myocardial damage in group P, MP, Y and M was similar to that in NE group. R and PR groups were less severe than those in NE group (P <0.01). Myocardium in NE group and MP group had obvious metabolic disorders, while R group was closer to normal. It is suggested that the α receptors, especially the α 1 receptors, play a major role in myocardial damage induced by NE. The author discusses the mechanism of its occurrence and puts forward new hypotheses.