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目的探讨肝病患者血清胱抑素C、肌酐(Scr)、尿素(BUN)指标变化的临床意义。方法采集112例肝病患者和65例正常健康体检者的外周血,检测血清胱抑素C、肌酐、尿素水平并进行对比分析。结果慢性肝炎患者、肝硬化肝功能失代偿期患者,血清胱抑素C水平均显著高于对照组(P<0.01)。慢性肝炎患者、肝硬化肝功能失代偿期患者血清肌酐、尿素与对照组比较无统计学意义(P>0.05)。肝肾综合征患者三项检测指标水平均显著高于对照组(P<0.01)。结论血清胱抑素C与慢性肝病病程的进展相关,检测肝病患者的血清胱抑素C有助于辅助诊断肝脏损伤程度及评估预后。
Objective To investigate the clinical significance of serum cystatin C, creatinine (Scr) and urea (BUN) in patients with liver disease. Methods Peripheral blood samples of 112 patients with liver disease and 65 healthy controls were collected. Serum levels of cystatin C, creatinine and urea were measured and compared. Results The levels of serum cystatin C in patients with chronic hepatitis and cirrhosis with decompensated liver were significantly higher than those in the control group (P <0.01). In patients with chronic hepatitis, serum creatinine and urea in patients with cirrhosis and liver decompensation had no statistical significance (P> 0.05). Liver and kidney syndrome patients with three test indicators were significantly higher than the control group (P <0.01). Conclusions Serum cystatin C is associated with the progression of chronic liver disease. Detection of serum cystatin C in patients with liver diseases may be helpful to diagnose the degree of liver injury and evaluate the prognosis.