论文部分内容阅读
目的探讨成人IgM肾病临床及病理特点。方法 43例IgM肾病患者根据临床表现分为肾病综合征组(A组,19例)、非肾病综合征组(B组,24例),分析两组患者的临床及病理特点。结果 A组24-h尿蛋白、血压、血清IgM水平和血沉高于B组,血清白蛋白和IgG水平低于B组(P<0.05)。A组和B组肾脏中IgM荧光强度与系膜增生、24-h尿蛋白和血清IgM水平呈正相关。两组电镜下见足突部分、广泛融合。结论 IgM肾病作为成人原发性肾小球肾炎之一,临床表现多样,以肾病综合征为主。有肾病综合征表现者临床表现和病理病变均较重。
Objective To investigate the clinical and pathological features of adult IgM nephropathy. Methods 43 patients with IgM nephropathy were divided into nephrotic syndrome group (A group, 19 cases) and non-nephrotic syndrome group (B group, 24 cases) according to clinical manifestations. The clinical and pathological features of the two groups were analyzed. Results 24-h urinary protein, blood pressure, serum IgM level and erythrocyte sedimentation rate in group A were higher than those in group B, serum albumin and IgG levels were lower in group A than those in group B (P <0.05). IgM fluorescence intensity in kidney of group A and group B was positively correlated with mesangial proliferation, 24-h urinary protein and serum IgM level. Two groups of electron microscopy foot process, a wide range of fusion. Conclusion IgM nephropathy as one of adult primary glomerulonephritis, clinical manifestations of diverse, mainly nephrotic syndrome. Nephrotic syndrome showed clinical manifestations and pathological lesions were heavier.