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本文观察了低体温对肺循环的影响,并探讨了交感神经在其中的作用。低温时(33.5±0.19℃)动物心输出量下降,肺动脉压升高,肺血管阻力增加51.6％,肺嵌压变化不明显。体温下降时血浆去甲肾上腺素浓度明显升高,但不影响动脉血气值。派唑嗪可以阻止低温引起的肺动脉高压,心得安对低温时肺循环变化无明显影响。结果表明:低温所致肺动脉高压,是由于交感神经兴奋,去甲肾上腺素释放增加,通过α_1肾上腺素能受体,促使肺动脉收缩,导致肺动脉高压形成。
This article examines the effects of hypothermia on pulmonary circulation and discusses the role of sympathetic nerves in it. Low temperature (33.5 ± 0.19 ℃) decreased cardiac output, pulmonary hypertension, pulmonary vascular resistance increased 51.6%, pulmonary pressure was not significantly changed. Plasma norepinephrine concentration was significantly increased when the temperature dropped, but did not affect arterial blood gas values. Prazosin can prevent hypothermia caused by pulmonary hypertension, propofol no significant changes in pulmonary circulation at low temperature. The results showed that: hypothermia caused by pulmonary hypertension, is due to sympathetic excitation, norepinephrine release increased by α 1 adrenergic receptors, to promote pulmonary artery contraction, leading to the formation of pulmonary hypertension.