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目的分析慢性阻塞性肺疾病(COPD)合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS),即重叠综合征患者睡眠呼吸紊乱的临床特点,比较门诊和住院COPD患者的呼吸紊乱情况。方法对Epworth嗜睡量表评分≥10,夜间氧减饱和指数ODI4(每小时血氧饱和度下降4%的次数)≥5的门诊及住院稳定期300例COPD患者进行多导睡眠图监测。结果住院COPD患者的呼吸紊乱程度更严重,住院与门诊COPD合并OSAHS患者在体重指数、血氧饱和度低于90%的时间占总记录时间的百分比、夜间平均血氧饱和度、夜间最低血氧饱和度、呼吸紊乱指数等方面差异显著。此外,住院COPD患者睡眠中心率增快。结论睡眠呼吸紊乱可以影响并加重COPD患者病情。
Objective To analyze the clinical features of chronic obstructive pulmonary disease (COPD) complicated with obstructive sleep apnea-hypopnea syndrome (OSAHS), the sleep-disordered breathing disorder in patients with overlapping syndromes and to compare the respiratory disorders in outpatients and hospitalized patients with COPD. Methods Polysomnography was performed in 300 outpatients with out-of-hospital and in-hospital stable COPD with Epworth Sleepiness Scale ≥10, Night Oxygen Desaturation Index ODI4 (4% decrease of oxygen saturation per hour) ≥5. Results In-hospital COPD patients had more severe respiratory disturbance. The differences of body mass index, percentage of oxygen saturation less than 90%, total nocturnal oxygen saturation, nocturnal nocturnal oxygen saturation Saturation, respiratory disorders index differences significantly. In addition, hospitalized patients with COPD sleep center rate increased. Conclusion Sleep-disordered breathing can affect and aggravate the condition of COPD patients.