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目的:探讨急性脑梗死患者血浆一氧化氮(NO)和一氧化氮合酶(NOS)与病情严重程度的关系。方法:收集确诊急性脑梗死患者126例为实验组,健康体检者78例为对照组,头颅CT测量急性脑梗塞面积,采用脑卒中量表(NIHSS)评分法评价神经功能,分别采用硝酸还原酶法和化学比色法测定血浆NO水平和NOS活性,分析NO和NOS水平与梗死面积及神经功能损害程度的相关性。结果:与健康对照组比较,急性脑梗死组血浆NO和NOS水平均高于对照组(P<0.05);急性脑梗死患者血浆NO和NOS水平在不同的梗死面积以及不同NIHSS评分中的差异均有统计学意义(P<0.05)。结论:急性脑梗死NO和NOS水平均显著升高,可能与其加重脑梗死神经功能损害有关,两者联合检测更有利于急性脑梗死的诊断和病情判断。
Objective: To investigate the relationship between plasma nitric oxide (NO) and nitric oxide synthase (NOS) and the severity of the disease in patients with acute cerebral infarction. Methods: A total of 126 patients with acute cerebral infarction were selected as the experimental group and 78 healthy controls as control group. The area of acute cerebral infarction was measured by cranial CT, and the neurological function was assessed by the National Institutes of Health Stroke Scale (NIHSS). Nitric acid reductase Plasma and nitric oxide synthase (NOS) activity were measured by the method of colorimetric assay and chemical colorimetry. The relationship between NO and NOS level and infarct size and neurological impairment were analyzed. Results: Compared with the healthy control group, plasma NO and NOS levels in acute cerebral infarction group were significantly higher than those in control group (P <0.05). The differences of NO and NOS levels in patients with acute cerebral infarction between different infarct sizes and different NIHSS scores There was statistical significance (P <0.05). CONCLUSION: The levels of NO and NOS in acute cerebral infarction are significantly increased, which may be related to their aggravating neurological deficits in cerebral infarction. The combined detection of them is more beneficial to the diagnosis and assessment of acute cerebral infarction.