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[目的]探讨糖尿病对阿尔茨海默病(Alzheimer’s Disease)发生的危险性。[方法]通过中国期刊网、HighWire Press、Medline等数据库搜集资料,然后应用RevMan5.0软件对所得资料进行Meta分析,选用随机效应模型进行合并效应量。[结果]经过文章质量的评价,筛选出可用文献9篇,其中包括病例对照研究5篇,队列研究4篇,纳入病例1258人,对照7708人。在对病例-对照文献的分析后得出的结果有显著性(OR=2.27,95%CI:1.39～3.68),而对队列研究的分析结果却与病例对照的结果有一定的差异(OR=1.31,95%CI:0.96～1.80),最后对两类文献资料进行合并分析后得出的结果具有显著性(OR=1.82,95%CI:1.24～2.68)。[结论]糖尿病可能是阿尔茨海默病发生的一个危险因素。
[Objective] To explore the risk of diabetes in Alzheimer’s Disease. [Method] The data were collected through the China Journal Net, HighWire Press, Medline and other databases. The data were then analyzed by Meta-analysis using RevMan 5.0 software and the random effect model was used for the combined effect. [Results] After evaluating the quality of articles, 9 available articles were screened, including 5 case-control studies and 4 cohort studies, including 1258 cases and 7708 controls. The results of the case-control literature were statistically significant (OR = 2.27, 95% CI: 1.39-3.68), whereas the results of the cohort study were somewhat different from those of the case-control subjects (OR = 1.31, 95% CI: 0.96-1.80). Finally, the combined results of two kinds of literature data were significant (OR = 1.82, 95% CI: 1.24-2.68). [Conclusion] Diabetes mellitus may be a risk factor for Alzheimer’s disease.