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目的探讨多西他赛联合腹腔热灌注顺铂治疗卵巢癌腹腔积液的临床效果。方法选择2011年1月—2012年12月收治的卵巢癌腹腔积液患者34例,随机分为观察组18例和对照组16例,均治疗9周后,比较两组肿瘤控制情况、腹腔积液控制情况、Karnofsky功能状态评分及不良反应。计数资料采用确切概率法,P<0.05为差异有统计学意义。结果治疗后肿瘤控制有效率观察组(88.9%)与对照组(25.0%)比较差异有统计学意义(P<0.05);腹腔积液控制有效率,Karnofsky功能状态评分改善率观察组(88.9%、55.6%)与对照组(75.0%、43.8%)比较差异均无统计学意义(均P>0.05)。结论多西他赛联合腹腔热灌注顺铂治疗卵巢癌腹腔积液不仅能控制腹腔积液,改善患者Karnofsky功能状态评分,还能控制卵巢肿瘤,安全性好,值得推广。
Objective To investigate the clinical efficacy of docetaxel in combination with intraperitoneal hot perfusion of cisplatin in the treatment of ascites of ovarian cancer. Methods From January 2011 to December 2012, 34 patients with ovarian cancer were randomly divided into observation group (n = 18) and control group (n = 16). After treatment for 9 weeks, the tumor control, Fluid control, Karnofsky functional status score and adverse reactions. Counting data using the exact probability method, P <0.05 for the difference was statistically significant. Results After treatment, the effective rate of tumor control in observation group (88.9%) was significantly lower than that in control group (25.0%) (P <0.05); the rate of effective control of ascites, the improvement rate of Karnofsky functional status score observation group (88.9% , 55.6%) compared with the control group (75.0%, 43.8%), there was no significant difference (all P> 0.05). Conclusion Docetaxel combined with intraperitoneal hot perfusion of cisplatin in the treatment of ovarian cancer ascites not only can control the peritoneal effusion, improve patients’ Karnofsky functional status score, but also control the ovarian tumor, which is safe and worthy of promotion.