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目的:探讨早期2型糖尿病肾病的危险因素与防治策略。方法:随机选取120例2型糖尿病患者为研究对象,其中60例为早期糖尿病肾病患者(实验组),60例为尿蛋白正常的患者(对照组),观察2组患者的临床及生化指标。结果:病程、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、血压、总胆固醇(TC)、甘油三酯(TG)、胰岛素抵抗、FIB、Hcy及SUA为影响早期2型糖尿病肾病的危险因素。结论:DN的危险因素主要与胰岛素抵抗、血胆固醇(TC)、FIB及24 h UUA排量增加有关。降血糖、降血压、降尿酸、低蛋白饮食、运动、药物等可以减少早期DN的发生。
Objective: To explore the risk factors and prevention and cure strategies of early type 2 diabetic nephropathy. Methods: A total of 120 patients with type 2 diabetes mellitus were randomly selected, 60 patients with early diabetic nephropathy (experimental group) and 60 patients with normal urinary protein (control group). The clinical and biochemical indexes of 2 patients were observed. Results: The duration of disease, fasting blood glucose (FBG), HbA1c, blood pressure, total cholesterol (TC), triglyceride (TG), insulin resistance, FIB, Hcy and SUA were the risk factors of early type 2 diabetic nephropathy. Conclusion: The risk factors of DN are mainly related with the increase of insulin resistance, blood cholesterol (TC), FIB and 24 h UUA. Hypoglycemia, blood pressure, uric acid, low protein diet, exercise, drugs can reduce the incidence of early DN.