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４－个甲氧基－２－巯基－Ｎ－氧化吡啶钠（４－甲氧基巯氧吡啶钠，ＳｏｄｉｕｍＭｅｔｈｏｘｙｐｙｒｉｄｉｎｅｔｈｉｏｎｅ，ＳＭＰＴ）在试管内０．０１ｍｇ·Ｌ－１可抑制多种传代人癌细胞林，抑制细胞有丝分裂和损害细胞膜相结构，单用对动物移植性肿瘤无效，但明显增强氟脲嘧啶对小鼠Ｓ１８０的抑癌作用。使胸腺和脾脏重量明显减轻，抑制ＳＲＢＣ诱导的小鼠血清溶血素反应，抑制ＤＮＣＢ诱导的豚鼠皮肤迟发型超敏反应，抑制ＰＨＡ诱导的大鼠３Ｈ－ＴｄＲ参入的淋巴细胞转化。与２－巯基－Ｎ－氧化吡啶钠（巯氧吡啶钠，ＳｏｄｉｕｍＰｙｒｉｄｉｎｅｔｈｉｏｎｅ．ＳＰＴ）比较，小鼠ＬＤ５０（ｉｐ）增大，而试管内抑瘤的ＩＣ５０相近。
4-Methoxy-2-mercapto-N-pyridinethiolate (Sodium Methoxypyridinethione, SMPT) 0.01mg · L-1 in vitro inhibits a variety of passaged human cancer cell lines , Inhibit cell mitosis and damage the cell membrane phase structure, single animal transplantation tumor is invalid, but significantly enhanced fluorouracil S180 tumor suppressor effect in mice. The weight of thymus and spleen is obviously reduced, the hemolysin reaction of mice induced by SRBC is inhibited, the delayed type hypersensitivity of guinea pigs induced by DNCB is inhibited, and the PHA-induced lymphocyte transformation induced by 3H-TdR is also inhibited. The LD50 (ip) of mice increased compared with sodiumPyridinethione.SPT, while the IC50 of anti-tumor in vitro was similar.