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目的:探讨前哨淋巴结定位与活组织检查在胃癌根治术中的作用。方法:使用亚甲蓝对22例胃癌患者先行前哨淋巴结标识活组织检查,然后行标准胃癌根治术,术后行常规HE病理及免疫组化检查,通过前哨淋巴结计算胃癌淋巴结转移诊断的准确率、敏感性及假阴性率。结果:22例患者中21例成功检出前哨淋巴结,检出率为95.5%(21/22)。前哨淋巴结预测胃周淋巴结转移的准确率为95.2%(20/21),敏感性为94.1%(16/17),特异性为100%(21/21),假阴性率为5.9%(1/17)。结论:术中使用亚甲蓝染色定位胃癌前哨淋巴结安全可行,并能准确反映胃癌周围淋巴结的转移状态。可用于指导胃癌的淋巴结清扫范围。
Objective: To investigate the role of sentinel lymph node localization and biopsy in radical resection of gastric cancer. Methods: Sentinel lymph node biopsy was performed in 22 patients with gastric cancer using methylene blue before standard gastric cancer radical resection. The patients were followed up for routine HE pathology and immunohistochemistry. The accuracy of diagnosis of lymph node metastasis of gastric cancer was calculated by sentinel lymph node, Sensitivity and false negative rate. Results: Out of 22 patients, 21 cases were successfully detected with sentinel lymph node, the detection rate was 95.5% (21/22). The accuracy of sentinel lymph node metastasis was 95.2% (20/21), the sensitivity was 94.1% (16/17), the specificity was 100% (21/21) and the false negative rate was 5.9% (1 / 17). Conclusion: Intraoperative use of methylene blue staining for sentinel lymph node metastasis is safe and feasible, and can accurately reflect the status of lymph node metastasis in gastric cancer. Can be used to guide the lymph node dissection range of gastric cancer.