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本文研究了正常人极低密度脂蛋白（ｖｅｒｙｌｏｗｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎ，ＶＬＤＬ）两种亚组分，即贫含载脂蛋白Ｅ的ＶＬＤＬ和富含载脂蛋白Ｅ的ＶＬＤＬ对小鼠腹腔巨噬细胞（ｍｏｕｓｅｐｅｒｉｔｏｎｅａｌｍａｃｒｏｐｈａｇｅ，ＭＰＭ）脂质堆积的影响。将贫含载脂蛋白Ｅ的ＶＬＤＬ和富含载脂蛋白Ｅ的ＶＬＤＬ分别与ＭＰＭ温育２４ｈ后，细胞内甘油三酯（ｔｒｉｇｌｙｃｅｒｉｄｅ，ＴＧ）和胆固醇酯（ｃｈｏｌｅｓｔｅｒｙｌｅｓｔｅｒ，ＣＥ）随ＶＬＤＬ浓度的增加而增加（方差分析，Ｐ＜０．０５），且对ＭＰＭ内ＴＧ的增加量以贫含载脂蛋白Ｅ的ＶＬＤＬ居多（Ｐ＜０．０１），而对ＭＰＭ内ＣＥ的增加量两者无显著性差异（Ｐ＞０．０５）。这提示，贫含载脂蛋白Ｅ的ＶＬＤＬ和富合载脂蛋白Ｅ的ＶＬＤＬ均能促进ＭＰＭ内ＴＧ、ＣＥ堆积，从而使巨噬细胞（ｍａｃｒｏｐｈａｇｅ，ＭＰ）转变为泡沫细胞。
In this paper, two sub-components of normal human very-low density lipoprotein (VLDL), namely, VLDL depleted in apolipoprotein E and VLDL enriched in apolipoprotein E, were used to treat mouse peritoneal macrophage (MPM) Effect of lipid accumulation. After incubation of apolipoprotein E-deficient VLDL and Apolipoprotein A-enriched VLDL with MPM for 24 h, triglyceride (TG) and cholesterylester (CE) increased with the increase of VLDL concentration (ANOVA, P <0.05), and the increase of TG in MPM was mostly in VLDL with apolipoprotein E deficiency (P <0.01), but not with the increase of CE in MPM Sex differences (P> 0.05). This suggests that both apolipoprotein E-deficient VLDL and apolipoprotein E-rich VLDL can promote accumulation of TG and CE in MPM, thereby converting macrophage (MP) cells into foam cells.