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对482名新生儿免疫接种乙肝疫苗随访观察11年,得到令人鼓舞的结果:各免疫组幼儿的HBsAg阳性率(2.02％～3.17％)显著低于对照组(9.35％)。接种疫苗后抗-HBs水平随着时间的推移不断下降,但接种对象中未出现与HBV感染有关的ALT异常者。乙肝疫苗的应用也明显降低了HBsAg阳性母亲对其子女的HBV感染率。本文调查结果显示了乙肝疫苗的良好结果。
A total of 482 newborns were immunized with hepatitis B vaccine for 11 years. An encouraging result was obtained: the positive rate of HBsAg in infants in each immunization group (2.02% -3.71%) was significantly lower than that in the control group (9.35%). Anti-HBs levels after vaccination declined over time, but none of the subjects with ALT abnormalities associated with HBV infection were present. The use of hepatitis B vaccine also significantly reduced the HBV infection rate of their children by HBsAg-positive mothers. The findings in this paper show good results for hepatitis B vaccine.