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目的：探讨精神分裂症患者发病年龄与静息态脑功能局部一致性（ReHo）之间的关系。方法选取19名45～59岁符合《精神障碍诊断与统计手册（第4版）》（DSM -Ⅳ）精神分裂症诊断标准的精神分裂症患者为被试。以发病年龄25岁为分界线，将患者分为25岁之前发病的早期发病患者组9名和25岁之后发病的晚期发病患者组10名，采集静息态功能磁共振数据，对比两组 ReHo 值。结果相对于早期发病的精神分裂症患者，晚期发病组大脑右侧额上回处的 ReHo 值显著降低（P ＜0.01，簇大小＞486mm3）。同时，右侧额上回处的 ReHo 均值与精神分裂症病程呈正相关，即个体病程越短，该脑区的 ReHo 值越低。结论患者发病年龄越早、病程越长，对右侧额上回功能同步性越明显。“,”Objective To explore the relationship between the age of onset and the regional homogeneity(ReHo)in schizophre-nia patients. Methods Nighteen schizophrenia patients who were diagnosed using the structured clinical interview for DSM - IV were included in this study. They were divided into early onset patients and late onset patients which defined by an onset of schizophrenia before or after 25 years old. The resting - state fMRI data was collected from all subjects. The ReHo results were compared between groups. Results Compared with the early onset patients,the late onset patients showed significant reduced ReHo value in right superi-or frontal gyrus. In addition,the ReHo value in the right superior frontal gyrus exhibited significant possitive correlationship with the duration of disease. Conclusion The right superior frontal gyrus is related with the age of onset of schizophrenia. We suggested that the superior frontal gyrus may be an important target for antipsychotic treatmen.