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生胃酮钠治疗十二指肠溃疡已有大量的报告,有关疗效的意见尚不一致,一般与用药期太短及单纯依赖放射学检查进行判断有关。本文报告经内窥镜确诊为十二指肠溃疡的门诊病人16例,用生胃酮钠50毫克的胶囊,三餐与睡前各1次,每日服200毫克,持续治疗12周;同时有双盲对照研究者18例。病人每2周随访1次,并测定血液生化及血清生胃酮的浓度:于治疗的4、8和12周复查内窥镜。研究结果表明,生胃酮钠组溃疡愈合率(4周69%,8周81%和12周76%)较安慰剂组(4周22%,
There are a lot of reports on the treatment of duodenal ulcer with sodium bicarbonate. The opinions on the therapeutic effect are not consistent. Generally, it is related to the medication period being too short and relying solely on radiological examination. In this paper, 16 cases of out-patient diagnosed as endoscopic duodenal ulcer were reported in this paper. Capsules of 50 mg sodium bicarbonate were used for three meals and one time before going to bed, 200mg daily for 12 weeks. Meanwhile, There are 18 double-blind control study. Patients were followed up every 2 weeks and blood biochemical and serum creatinine concentrations were measured: endoscopes were reviewed at 4, 8 and 12 weeks of treatment. The results showed that the rate of ulcer healing in the ketamine sodium group (69% for 4 weeks, 81% for 8 weeks and 76% for 12 weeks) was significantly higher than that for placebo group (22% for 4 weeks,